Phospho sting
WebPhospho-STING (Ser366) (D8K6H) Rabbit mAb recognizes endogenous levels of STING protein only when phosphorylated at Ser366. Species Reactivity: Human Source / … WebPhospho-STING (Ser365) Antibody (PA5-117271) in WB Western blot analysis of extracts of THP-1 cells using Phospho-STING (Ser365) Polyclonal Antibody (Product # PA5-117271). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Product Details
Phospho sting
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WebJan 29, 2015 · STING is an essential adaptor protein in the cytosolic DNA sensing pathway that also activates IRF3 . Recently, STING Ser 366 was shown to be important in IRF3 … WebThe Mouse Phospho-STING (Ser365) assay measures mouse STING when phosphorylated at Ser365. Unlike Western Blot, the assay is entirely plate-based and does not require gels, …
WebJun 7, 2024 · The assay showed the dependency of STING phosphorylation on the STING agonist, TBK1, “ER-to-Golgi” traffic, and palmitoylation, which mirrored the nature of … WebA common control for phospho-specific antibodies involves treating your lysates with calf intestinal phosphatase or lambda protein phosphatase. If the antibody is phospho-specific, the signal will disappear after phosphatase treatment (Figure 1).
WebMay 28, 2024 · STING activation has been shown to be a promising strategy to treat cancers, leading to the development of small-molecule agonists (9, 36). diABZI is a small-molecule, non-CDN STING agonist that is more potent than endogenous CDNs . diABZI significantly suppresses SARS-CoV-2 infection in primary and transformed human … WebInterestingly, we found that STING interacts with both TBK1 and IRF3, and that mutations in STING that selectively disrupt its binding to IRF3 abrogate IRF3 phosphorylation without impairing TBK1 activation. ... IRF3 also bound to phospho-TBK1 [TRAF family member-associated NFκB activator (TANK)-binding kinase] (Fig. 4 E and G), which is a ...
Web55. A method of treating, inhibiting, reducing, ameliorating, and/or preventing a cancer and or metastasis in a subject comprising administering to a subject an adoptive immunothe
WebSTING activation in patient tumors and in platinum-treated preclinical NSCLC models was correlated with biomarkers of immunotherapy response. Results: STING activation is associated with higher levels of intrinsic DNA damage, targetable immune checkpoints, and chemokines in treatment-naive and relapsed lung adenocarcinoma. cit bank cd no penaltyWebJan 13, 2024 · STING (stimulator of interferon genes) is an important innate immune protein, but its homeostatic regulation at the resting state is unknown. Here, we identified TOLLIP as a stabilizer of STING... cit bank chandlerWebPhospho-STING (Ser366) (D8K6H) Rabbit mAb (Alexa Fluor ® 647 Conjugate) recognizes endogenous levels of STING protein only when phosphorylated at Ser366. Species … cit bank cd rateWebCell Signaling Technology's Phospho-STING (Ser366) (D7C3S) Rabbit mAb is a Rabbit monoclonal antibody. The Phospho-STING (Ser366) (D7C3S) Rabbit mAb Antibody was generated using stimulator of interferon response cGAMP interactor 1, and STING1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such … cit bank chandler branchWebThe Mouse Phospho-STING (Ser365) assay measures mouse STING when phosphorylated at Ser365. Unlike Western Blot, the assay is entirely plate-based and does not require gels, electrophoresis, or transfer. The Mouse Phospho-STING (Ser365) assay uses 2 labeled antibodies: one with a donor fluorophore, the other one with an acceptor. diana\\u0027s last words before dyingWebPhospho-STING (Ser366) (D8K6H) Rabbit mAb (Alexa Fluor ® 488 Conjugate) #41622 Product Description. This Cell Signaling Technology antibody is conjugated to Alexa Fluor … cit bank ceoWebJul 7, 2024 · The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C … cit bank cds rates