WebTo test the hypothesis that small molecule targeting of nucleophosmin 1 (NPM1) represents a rational approach for radiosensitization. Wilde-type and NPM1-deficient mouse embryo fibroblasts (MEFs) were used to determine whether radiosensitization produced by the small molecule YTR107 was NPM1 dependent. The stress response to ionizing … Web16 nov. 2007 · NPM1/Nucleophosmin/B23, also termed NO38 or numatrin, is an acidic nucleolar protein that plays multiple roles in cell growth and proliferation. In general, the expression level of B23 is proportional to the cell growth rate, suggesting that it plays a positive role(s) in cell growth and proliferation.

The potential role of nucleophosmin (NPM1) in the development …

WebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity and specificity. - Long-term security of supply. - Animal-free production. For more information see here. Our RabMAb ® technology is a patented hybridoma-based technology ... Nucleophosmin has multiple functions: Histone chaperones; Ribosome biogenesis and transport; Genomic stability and DNA repair; Endoribonuclease activity; Centrosome duplication during cell cycle; Regulation of ARF-p53 tumor suppressor pathway; RNA helix destabilizing activity; Inhibition of … Meer weergeven Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene. Meer weergeven NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist … Meer weergeven NPM1 has been shown to interact with • AKT1, • BARD1, • BRCA1, and Meer weergeven NPM1 gene is up-regulated, mutated and chromosomally translocated in many tumor types. Chromosomal aberrations involving NPM1 were found in patients with Meer weergeven • Yun C, Wang Y, Mukhopadhyay D, Backlund P, Kolli N, Yergey A, Wilkinson KD, Dasso M (November 2008). "Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases" Meer weergeven hotels with a honeymoon suite near me

Aleksandr Kostarev – Researcher Phd Candidate

WebNucleophosmin (NPM, B23, NO38, numartrin) is a multifunctional phoshoprotein mainly located to nucleoli. NPM can shuttle between the nucleus and cytoplasm and has a … Web12 jun. 2024 · Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein involved in ribosome biogenesis, the maintenance of genomic integrity and the regulation of the ARF-p53 tumor-suppressor pathway among multiple other functions. Mutations in the corresponding gene cause a cytoplasmic dislocation of the NPM1 protein. These … WebNucleophosmin mutation in Southeast Asian acute myeloid leukemia: eight novel variants, FLT3 coexistence and prognostic impact of NPM1/FLT3 mutations. haematologica, (2008); 93(10): 1565-1569. Marshall R, Tlagadi A, Bronze M, Kana V, Naidoo S, et al. Lower frequency of NPM 1 and FLT 3‐ITD mutations in a South African adult de novo AML cohort. lincoln power mig 350mp settings